Klotho expression

Author: rpyk

August undefined, 2024

WebExpression of EpoR and Klotho protein by mouse bone marrow cells. Notes: To confirm that mouse bone marrow cells expressed EpoR and Klotho, these cells were assayed by flow cytometry. Aliquots of 10 6 bone marrow cells were incubated with anti-EpoR–FITC and anti-Klotho–PE antibodies, and the cells were analyzed on an FACS Aria flow ... WebOct 22, 2024 · During the past 20 years, increasing evidence from clinical and basic studies has indicated that klotho, which was initially known as an anti-aging gene and is mainly …

The role of Klotho and FGF23 in cardiovascular outcomes of …

National Center for Biotechnology Information WebKlotho is an aging suppressor gene that encodes a single-pass transmembrane protein expressed in multiple tissues, with the highest expression in the renal tubules, parathyroid … bursal cyst on hand

Klotho and SIRT1 Expression in Renal Aging Related Disease IJGM

WebAug 17, 2015 · Klotho is an aging suppressor gene that encodes a single-pass transmembrane protein expressed in multiple tissues, with the highest expression in the … WebAug 29, 2024 · Klotho expression was reduced in different types of cancer: breast, pancreatic, colon, ovarian, cervical, melanoma, hepatocellular carcinoma (HCC), renal cell carcinoma (RCC), gastric, large cell... WebThe effects of beta-Klotho and FGF-15 on the ileal apical sodium bile transporter (ASBT) are unknown. beta-Klotho siRNA treatment of the mouse colon cancer cell line, CT-26, and the … hampshire homes miramar

Klotho expression is a prerequisite for proper muscle …

WebDefinition of klotho in the Definitions.net dictionary. Meaning of klotho. What does klotho mean? Information and translations of klotho in the most comprehensive dictionary … WebJul 4, 2024 · Klotho expression is a prerequisite for proper muscle stem cell function and regeneration of skeletal muscle Authors Hellen E Ahrens 1 , Judith Huettemeister 1 2 , … bursal cyst spineWebSep 20, 2024 · Klotho was originally identified as a gene in mice when a defect in klotho gene expression resulted in effects that resembled human aging, such as cognitive … hampshire homes limited

"WebOct 1, 2015 · α-Klotho protein expression has been found in mice, rats, and humans predominantly in the renal distal convoluted tubular cells ( 1) and to a lesser extent in proximal convoluted tubular epithelial cells (PTECs) ( 13) and the parathyroid gland ( 14 ). We recently reported α-Klotho expression in human vasculature ( 11 ). " - Klotho expression

Klotho expression

Rapamycin-Induced Hypophosphatemia and Insulin Resistance …

WebNov 9, 2024 · Depleting klotho selectively from the choroid plexus via targeted viral vector-induced knockout in Klotho flox/flox mice increased the expression of multiple proinflammatory factors and triggered macrophage infiltration of this structure in young mice, simulating changes in unmanipulated old mice. Wild-type mice infected with the … WebOct 1, 2015 · α-Klotho protein expression has been found in mice, rats, and humans predominantly in the renal distal convoluted tubular cells and to a lesser extent in …

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Websenescence.10,11 However, the regulatory mechanisms underlying the downregulation of klotho expression in COPD remain unknown. In this study, we will use CSE-induced … WebJan 15, 2002 · Mice deficient in Klotho gene expression exhibit a syndrome resembling premature human aging. To determine whether variation in the human KLOTHO locus contributes to survival, we applied two newly characterized polymorphic microsatellite markers flanking the gene in a population-based association study. In a cohort chosen for …

WebKidney is the major site of Klotho expression. 5 Circulating blood Klotho levels are positively correlated with renal function, and high levels of Klotho contribute to the protection of … WebOct 18, 2013 · We found that the patterns of β-klotho expression and FGF21’s actions in db/db mouse islets followed these changes during the progression toward overt diabetes, suggesting that glucose itself is a potential mediator of islet FGF21 resistance. Our ex vivo experiments further demonstrated that prolonged high glucose exposure can dramatically ...

WebMar 1, 2024 · Background: Enhanced inflammation and reduced Klotho are common features in chronic kidney disease (CKD). Inflammation induces DNA hypermethylation. This study assessed the performance of inflammatory marker C-C motif chemokine 5 (CCL5) in epigenetic regulation of Klotho expression. WebKlotho deficiency activates Wnt expression and activity contributing to senescence and depletion of stem cells, which consequently triggers tissue atrophy and fibrosis. In contrast, the klotho protein was shown to suppress Wnt-signaling transduction, and inhibit cell senescence and preserve stem cells. A better understanding of the potential ...

WebApr 20, 2024 · Notably, Klotho overexpression in old mice reduced pathogenic expression of genes involved with cell structure, ion homeostasis, and signaling for muscle adiposity. …

WebApr 15, 2024 · Furthermore, drugs that inhibit the renin-angiotensin system promote Klotho expression and it is plausible this class of drugs could have better effects in patients who … bursal cyst vs ganglion cystWebJun 11, 2024 · Klotho is a natural protein enzyme that exists within the body and brain. This protein is created by the KL gene and is produced in the kidneys. It appears to have a large … hampshire hoopfestWebRobust RBM3 and β-klotho expression in developing neurons in the human brain RNA binding motif 3 (RBM3) is a powerful neuroprotectant that inhibits neurodegenerative cell death in vivo and is a promising therapeutic target in brain ischemia. bursa left knee icd10WebJan 21, 2024 · KP1 preserved kidney function, repressed TGF-β signaling, ameliorated renal fibrosis and restored endogenous Klotho expression. Together, our findings suggest that KP1 recapitulates the... hampshire honor society footballWebRapamycin, an immunosuppressive drug used to prevent rejection after kidney transplantation, influences phosphate homeostasis, induces insulin resistance and has been shown to prolong lifespan in animal models. Because Klotho is an aging-suppressor gene controlling phosphate metabolism and insulin sensitivity, we investigated the influence of … bursal cyst treatmentWebMay 11, 2024 · Klotho, a type I transmembrane protein, is an important components of FGF receptor complexes. Recent studies have reported the presence of Klotho expression in bone. However, the role of... hampshire hooves for saleWebApr 15, 2024 · Due to its high expression in the mammalian central nervous system (CNS), klotho has been the subject of numerous studies investigating its potential role in … bursal impingement on abduction